Comparative Simulation of 3-zone SMB (Simulated Moving Bed) and 4-zone SMB for IgY (Immunoglobulin Yolk) Purification

Prof. Dr. Volker Kasche Simulation of Liquid Chromatography and Simulated Moving Bed (SMB) Systems

Online 'cycle to cycle' optimizing control of Varicol and Simulated Moving Bed (SMB) processes

Moving Bed (SMB) processes Mohammad Amanullah, Cristian Grossmann, , Marco Mazzotti*, Manfred Morari, Massimo Morbidelli 1 Institute of Process Engineering, ETH Zurich, CH-8092 Zurich, Switzerland Automatic Control Laboratory, ETH Zurich, CH-8092 Zurich, Switzerland 3 Institute for Chemical and Bio-Engineering, ETH Zurich, CH-8093, Switzerland * Corresponding author: [email protected]...

Adsorption Properties, Mathematical Modelling, Optimization, Control and Supervision of Simulated Moving Bed (SMB) processes

Conventional batch chromatography is relatively inefficient in terms of adsorbent and solvent consumption and significant benefits can be achieved by performing separation of high-added value products, such as enantiomers produced in the pharmaceutical industry, with a simulated moving bed (SMB) process (Lehoucq et al., 2000). The SMB process allows a counter-current movement of the liquid and ...

Smb Takes on Paclitaxel Purification

Simulated Moving Bed (SMB) chromatography is an important technology for separating chiral compounds, but it can also be used in challenging purifications to remove impurities that are structurally similar to target compounds. Bioxel Pharma, Inc. has developed and implemented a fully automated, high throughput SMB process to remove cephalomannine from paclitaxel, an active pharmaceutical ingred...

Optimization of simulated moving bed (SMB) chromatography: a multi-level optimization procedure

This paper presents a multi-level optimization strategy to obtain optimum operating conditions (four flowrates and cycle time) of nonlinear simulated moving bed chromatography. The multi-level optimization procedure (MLOP) approaches systematically from initialization to optimization with two objective functions (productivity and desorbent consumption), employing the standing wave analysis, the...